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Small-molecule control of neurotransmitter sulfonation

Controlling unmodified serotonin levels in brain synapses is a primary objective when treating major depressive disorder—a disease that afflicts ∼20% of the world’s population. Roughly 60% of patients respond poorly to first-line treatments and thus new therapeutic strategies are sought. To this end...

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Detalles Bibliográficos
Autores principales: Cook, Ian, Cacace, Mary, Wang, Ting, Darrah, Kristie, Deiters, Alexander, Leyh, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948405/
https://www.ncbi.nlm.nih.gov/pubmed/33485192
http://dx.doi.org/10.1074/jbc.RA120.015177