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The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis

Proper brain development and function requires finely controlled mechanisms for protein turnover, and disruption of genes involved in proteostasis is a common cause of neurodevelopmental disorders. Kelch-like 15 (KLHL15) is a substrate adaptor for cullin3-containing E3 ubiquitin ligases, and KLHL15...

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Detalles Bibliográficos
Autores principales:	Song, Jianing, Merrill, Ronald A., Usachev, Andrew Y., Strack, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948412/ https://www.ncbi.nlm.nih.gov/pubmed/33199366 http://dx.doi.org/10.1074/jbc.RA120.016210

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