Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24

The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in the genes encoding either prelamin A or ZMPSTE24 tha...

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Detalles Bibliográficos
Autores principales: Babatz, Timothy D., Spear, Eric D., Xu, Wenxin, Sun, Olivia L., Nie, Laiyin, Carpenter, Elisabeth P., Michaelis, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948416/
https://www.ncbi.nlm.nih.gov/pubmed/33293369
http://dx.doi.org/10.1074/jbc.RA120.015792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948416/
https://www.ncbi.nlm.nih.gov/pubmed/33293369
http://dx.doi.org/10.1074/jbc.RA120.015792

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