Cargando…

Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24

The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in the genes encoding either prelamin A or ZMPSTE24 tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Babatz, Timothy D., Spear, Eric D., Xu, Wenxin, Sun, Olivia L., Nie, Laiyin, Carpenter, Elisabeth P., Michaelis, Susan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948416/ https://www.ncbi.nlm.nih.gov/pubmed/33293369 http://dx.doi.org/10.1074/jbc.RA120.015792

Ejemplares similares

Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24
por: Wood, Kaitlin M., et al.
Publicado: (2020)

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
por: Spear, Eric D., et al.
Publicado: (2018)

Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24
por: Barrowman, Jemima, et al.
Publicado: (2012)

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice
por: Wang, Yuexia, et al.
Publicado: (2022)

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24
por: Mehmood, Shahid, et al.
Publicado: (2016)

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation
por: Shilagardi, Khurts, et al.
Publicado: (2022)

ZMPSTE24 defends against influenza and other pathogenic viruses
por: Fu, Bishi, et al.
Publicado: (2017)

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
por: Messner, Moritz, et al.
Publicado: (2020)

Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites
por: Wang, Yanan, et al.
Publicado: (2017)

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24(−/−) Progeria Mouse Model
por: Hambright, William S., et al.
Publicado: (2023)

JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome
por: Ambroggio, Xavier I, et al.
Publicado: (2004)

Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide
por: Akinci, Baris, et al.
Publicado: (2017)

Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous ZMPSTE24 Mutation
por: Lucas‐Herald, Angela K, et al.
Publicado: (2018)

Muscle-derived stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration
por: Song, Minjung, et al.
Publicado: (2013)

Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability
por: Kong, Keyu, et al.
Publicado: (2023)

Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology
por: Goblirsch, Brandon R., et al.
Publicado: (2020)

A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy
por: Galant, Damien, et al.
Publicado: (2016)

Accelerated aging induced by deficiency of Zmpste24 protects old mice to develop bleomycin-induced pulmonary fibrosis
por: Calyeca, Jazmín, et al.
Publicado: (2018)

Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency
por: Yao, Haidong, et al.
Publicado: (2020)

ZMPSTE24 Regulates SARS-CoV-2 Spike Protein–enhanced Expression of Endothelial PAI-1
por: Han, Mingming, et al.
Publicado: (2021)

Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity
por: Stott-Marshall, Robert J., et al.
Publicado: (2022)

Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
por: Suo, Jinlong, et al.
Publicado: (2023)

Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases
por: Rahman, Fatema, et al.
Publicado: (2021)

Metal Preferences of Zinc-Binding Motif on Metalloproteases
por: Fukasawa, Kayoko M., et al.
Publicado: (2011)

miR-342-5p promotes Zmpste24-deficient mouse embryonic fibroblasts proliferation by suppressing GAS2
por: Zhang, Chun-Long, et al.
Publicado: (2017)

Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site
por: Monfort, Jordi, et al.
Publicado: (2006)

Characterization of the zinc metalloprotease of Streptococcus suis serotype 2
por: Dumesnil, Audrey, et al.
Publicado: (2018)

Prelamin A and Oct-1: a puzzle of aging
por: Infante, Arantza, et al.
Publicado: (2015)

Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies
por: Brayson, Daniel, et al.
Publicado: (2019)

Correction: Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease 13 - identification of a new biglycan cleavage site
por: Monfort, Jordi, et al.
Publicado: (2013)

Prelaminated Temporoparietal Osteofascial Flap: A Novel Nasal Reconstruction Technique
por: Aldana, Celso A., et al.
Publicado: (2021)

A Function for a Specific Zinc Metalloprotease of African Trypanosomes
por: Grandgenett, Paul M, et al.
Publicado: (2007)

A novel animal model for skin flap prelamination with biomaterials
por: Zhou, Xianyu, et al.
Publicado: (2016)

Prelaminated Fascia Lata Free Flap for Oronasal Fistula Reconstruction
por: Cavadas, Pedro C., et al.
Publicado: (2017)

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells
por: Evangelisti, Camilla, et al.
Publicado: (2020)

InhA1-Mediated Cleavage of the Metalloprotease NprA Allows Bacillus cereus to Escape From Macrophages
por: Haydar, Abbass, et al.
Publicado: (2018)

A Novel Membrane-associated Metalloprotease, Ste24p, Is Required for the First Step of NH(2)-terminal Processing of the Yeast a-Factor Precursor
por: Fujimura-Kamada, Konomi, et al.
Publicado: (1997)

Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation
por: Imai, Rika, et al.
Publicado: (2015)

Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin
por: Bromberg-White, Jennifer, et al.
Publicado: (2010)

An archaeal protein evolutionarily conserved in prokaryotes is a zinc-dependent metalloprotease
por: Hu, Yongmei, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kdrbkubtkkv5okfbgr3ndu88eo