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Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors

Receptors for the peptide hormones glucagon-like peptide-1 (GLP-1R), glucose-dependent insulinotropic polypeptide (GIPR), and glucagon (GCGR) are important regulators of insulin secretion and energy metabolism. GLP-1R agonists have been successfully deployed for the treatment of type 2 diabetes, but...

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Detalles Bibliográficos
Autores principales:	Jones, Ben, McGlone, Emma Rose, Fang, Zijian, Pickford, Phil, Corrêa, Ivan R., Oishi, Atsuro, Jockers, Ralf, Inoue, Asuka, Kumar, Sunil, Görlitz, Frederik, Dunsby, Chris, French, Paul M.W., Rutter, Guy A., Tan, Tricia, Tomas, Alejandra, Bloom, Stephen R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948418/ https://www.ncbi.nlm.nih.gov/pubmed/33268378 http://dx.doi.org/10.1074/jbc.RA120.016334

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