Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41

[Image: see text] Human immunodeficiency virus type 1 (HIV-1) is mainly transmitted by sexual intercourse, and effective microbicides preventing HIV-1 transmission are still required. Amphibian skin is a rich source of defense peptides with antiviral activity. Here, we characterized a lectin-like pe...

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Autores principales: Xiong, Weichen, Zhou, Chenliang, Yin, Shuwen, Chai, Jinwei, Zeng, Baishuang, Wu, Jiena, Li, Yibin, Li, Lin, Xu, Xueqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948434/
https://www.ncbi.nlm.nih.gov/pubmed/33718732
http://dx.doi.org/10.1021/acsomega.1c00033
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author Xiong, Weichen
Zhou, Chenliang
Yin, Shuwen
Chai, Jinwei
Zeng, Baishuang
Wu, Jiena
Li, Yibin
Li, Lin
Xu, Xueqing
author_facet Xiong, Weichen
Zhou, Chenliang
Yin, Shuwen
Chai, Jinwei
Zeng, Baishuang
Wu, Jiena
Li, Yibin
Li, Lin
Xu, Xueqing
author_sort Xiong, Weichen
collection PubMed
description [Image: see text] Human immunodeficiency virus type 1 (HIV-1) is mainly transmitted by sexual intercourse, and effective microbicides preventing HIV-1 transmission are still required. Amphibian skin is a rich source of defense peptides with antiviral activity. Here, we characterized a lectin-like peptide, fejerlectin (RLCYMVLPCP), isolated from the skin of the frog Fejervarya limnocharis. Fejerlectin showed significant hemagglutination and d-(+)-galacturonic acid-binding activities. Furthermore, fejerlectin suppressed the early entry of HIV-1 into target cells by binding to the N-terminal heptad repeat of HIV-1 gp41 and preventing 6-HB formation and Env-mediated membrane fusion. Fejerlectin is the smallest lectin-like peptide identified to date and represents a new and promising platform for anti-HIV-1 drug development.
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spelling pubmed-79484342021-03-12 Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41 Xiong, Weichen Zhou, Chenliang Yin, Shuwen Chai, Jinwei Zeng, Baishuang Wu, Jiena Li, Yibin Li, Lin Xu, Xueqing ACS Omega [Image: see text] Human immunodeficiency virus type 1 (HIV-1) is mainly transmitted by sexual intercourse, and effective microbicides preventing HIV-1 transmission are still required. Amphibian skin is a rich source of defense peptides with antiviral activity. Here, we characterized a lectin-like peptide, fejerlectin (RLCYMVLPCP), isolated from the skin of the frog Fejervarya limnocharis. Fejerlectin showed significant hemagglutination and d-(+)-galacturonic acid-binding activities. Furthermore, fejerlectin suppressed the early entry of HIV-1 into target cells by binding to the N-terminal heptad repeat of HIV-1 gp41 and preventing 6-HB formation and Env-mediated membrane fusion. Fejerlectin is the smallest lectin-like peptide identified to date and represents a new and promising platform for anti-HIV-1 drug development. American Chemical Society 2021-02-24 /pmc/articles/PMC7948434/ /pubmed/33718732 http://dx.doi.org/10.1021/acsomega.1c00033 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Xiong, Weichen
Zhou, Chenliang
Yin, Shuwen
Chai, Jinwei
Zeng, Baishuang
Wu, Jiena
Li, Yibin
Li, Lin
Xu, Xueqing
Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41
title Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41
title_full Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41
title_fullStr Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41
title_full_unstemmed Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41
title_short Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41
title_sort fejerlectin, a lectin-like peptide from the skin of fejervarya limnocharis, inhibits hiv-1 entry by targeting gp41
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948434/
https://www.ncbi.nlm.nih.gov/pubmed/33718732
http://dx.doi.org/10.1021/acsomega.1c00033
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