Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination

[Image: see text] We described a silver(I)-mediated intramolecular oxidative C–H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indaz...

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Autores principales: Park, Areum, Jeong, Kyu-Sung, Lee, Hyuk, Kim, Hyunwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948442/
https://www.ncbi.nlm.nih.gov/pubmed/33718741
http://dx.doi.org/10.1021/acsomega.1c00025
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author Park, Areum
Jeong, Kyu-Sung
Lee, Hyuk
Kim, Hyunwoo
author_facet Park, Areum
Jeong, Kyu-Sung
Lee, Hyuk
Kim, Hyunwoo
author_sort Park, Areum
collection PubMed
description [Image: see text] We described a silver(I)-mediated intramolecular oxidative C–H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C–H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.
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spelling pubmed-79484422021-03-12 Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination Park, Areum Jeong, Kyu-Sung Lee, Hyuk Kim, Hyunwoo ACS Omega [Image: see text] We described a silver(I)-mediated intramolecular oxidative C–H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C–H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant. American Chemical Society 2021-02-23 /pmc/articles/PMC7948442/ /pubmed/33718741 http://dx.doi.org/10.1021/acsomega.1c00025 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Park, Areum
Jeong, Kyu-Sung
Lee, Hyuk
Kim, Hyunwoo
Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
title Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
title_full Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
title_fullStr Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
title_full_unstemmed Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
title_short Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
title_sort synthesis of 1h-indazoles via silver(i)-mediated intramolecular oxidative c–h bond amination
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948442/
https://www.ncbi.nlm.nih.gov/pubmed/33718741
http://dx.doi.org/10.1021/acsomega.1c00025
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