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How to extend your (polylactosamine) antennae
The elongated antennae decorating eukaryotic glycans are built from polylactosamine repeats. Polylactosamine forms a lectin recognition site and also acts as a platform for presenting diverse additional modifications (e.g., terminal cell-surface antigens); it therefore plays important roles in cell...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948483/ https://www.ncbi.nlm.nih.gov/pubmed/33453284 http://dx.doi.org/10.1016/j.jbc.2020.100212 |
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author | Kimber, Matthew S. |
author_facet | Kimber, Matthew S. |
author_sort | Kimber, Matthew S. |
collection | PubMed |
description | The elongated antennae decorating eukaryotic glycans are built from polylactosamine repeats. Polylactosamine forms a lectin recognition site and also acts as a platform for presenting diverse additional modifications (e.g., terminal cell-surface antigens); it therefore plays important roles in cell adherence, development, and immunity. Two new papers present a detailed structural and mechanistic investigation of β1-3-N-acetylgucosaminyltransferase 2, a key enzyme in antennae synthesis. The resulting insights will also help decipher other members of GT31, the single largest human glycosyltransferase family. |
format | Online Article Text |
id | pubmed-7948483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-79484832021-03-19 How to extend your (polylactosamine) antennae Kimber, Matthew S. J Biol Chem Editors' Pick Highlight The elongated antennae decorating eukaryotic glycans are built from polylactosamine repeats. Polylactosamine forms a lectin recognition site and also acts as a platform for presenting diverse additional modifications (e.g., terminal cell-surface antigens); it therefore plays important roles in cell adherence, development, and immunity. Two new papers present a detailed structural and mechanistic investigation of β1-3-N-acetylgucosaminyltransferase 2, a key enzyme in antennae synthesis. The resulting insights will also help decipher other members of GT31, the single largest human glycosyltransferase family. American Society for Biochemistry and Molecular Biology 2021-01-14 /pmc/articles/PMC7948483/ /pubmed/33453284 http://dx.doi.org/10.1016/j.jbc.2020.100212 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editors' Pick Highlight Kimber, Matthew S. How to extend your (polylactosamine) antennae |
title | How to extend your (polylactosamine) antennae |
title_full | How to extend your (polylactosamine) antennae |
title_fullStr | How to extend your (polylactosamine) antennae |
title_full_unstemmed | How to extend your (polylactosamine) antennae |
title_short | How to extend your (polylactosamine) antennae |
title_sort | how to extend your (polylactosamine) antennae |
topic | Editors' Pick Highlight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948483/ https://www.ncbi.nlm.nih.gov/pubmed/33453284 http://dx.doi.org/10.1016/j.jbc.2020.100212 |
work_keys_str_mv | AT kimbermatthews howtoextendyourpolylactosamineantennae |