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Structure of an ancestral ADP-dependent kinase with fructose-6P reveals key residues for binding, catalysis, and ligand-induced conformational changes

ADP-dependent kinases were first described in archaea, although their presence has also been reported in bacteria and eukaryotes (human and mouse). This enzyme family comprises three substrate specificities; specific phosphofructokinases (ADP-PFKs), specific glucokinases (ADP-GKs), and bifunctional...

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Detalles Bibliográficos
Autores principales:	Muñoz, Sebastián M., Castro-Fernandez, Victor, Guixé, Victoria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948494/ https://www.ncbi.nlm.nih.gov/pubmed/33839685 http://dx.doi.org/10.1074/jbc.RA120.015376

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