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Comparison of human poly-N-acetyl-lactosamine synthase structure with GT-A fold glycosyltransferases supports a modular assembly of catalytic subsites

Poly-N-acetyl-lactosamine (poly-LacNAc) structures are composed of repeating [-Galβ(1,4)-GlcNAcβ(1,3)-](n) glycan extensions. They are found on both N- and O-glycoproteins and glycolipids and play an important role in development, immune function, and human disease. The majority of mammalian poly-La...

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Detalles Bibliográficos
Autores principales:	Kadirvelraj, Renuka, Yang, Jeong-Yeh, Kim, Hyun W., Sanders, Justin H., Moremen, Kelley W., Wood, Zachary A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948508/ https://www.ncbi.nlm.nih.gov/pubmed/33229435 http://dx.doi.org/10.1074/jbc.RA120.015305

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