Targeting primary and metastatic uveal melanoma with a G protein inhibitor

Uveal melanoma (UM) is the most common intraocular tumor in adults. Nearly half of UM patients develop metastatic disease and often succumb within months because effective therapy is lacking. A novel therapeutic approach has been suggested by the discovery that UM cell lines driven by mutant constit...

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Detalles Bibliográficos
Autores principales: Onken, Michael D., Makepeace, Carol M., Kaltenbronn, Kevin M., Choi, Joelle, Hernandez-Aya, Leonel, Weilbaecher, Katherine N., Piggott, Kisha D., Rao, P. Kumar, Yuede, Carla M., Dixon, Alethia J., Osei-Owusu, Patrick, Cooper, John A., Blumer, Kendall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948511/
https://www.ncbi.nlm.nih.gov/pubmed/33577798
http://dx.doi.org/10.1016/j.jbc.2021.100403

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