Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis

Lipids in complex, protein-enriched films at air/liquid interfaces reduce surface tension. In the absence of this benefit, the light refracting and immunoprotective tear film on eyes would collapse. Premature collapse, coupled with chronic inflammation compromising visual acuity, is a hallmark of dr...

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Detalles Bibliográficos
Autores principales: Georgiev, Georgi A., Gh., Mohammad Sharifian, Romano, Jeff, Dias Teixeira, Karina L., Struble, Craig, Ryan, Denise S., Sia, Rose K., Kitt, Jay P., Harris, Joel M., Hsu, Ku-Lung, Libby, Adam, Odrich, Marc G., Suárez, Tatiana, McKown, Robert L., Laurie, Gordon W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948570/
https://www.ncbi.nlm.nih.gov/pubmed/33187980
http://dx.doi.org/10.1074/jbc.RA120.015833

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