Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation

Down syndrome (DS) is mainly caused by an extra copy of chromosome 21 (trisomy 21), and patients display a variety of developmental symptoms, including characteristic facial features, physical growth delay, intellectual disability, and neurodegeneration (i.e., Alzheimer’s disease; AD). One of the pa...

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Detalles Bibliográficos
Autores principales: Lee, Ye Hyung, Im, Eunju, Hyun, Minju, Park, Joongkyu, Chung, Kwang Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948726/
https://www.ncbi.nlm.nih.gov/pubmed/33380426
http://dx.doi.org/10.1074/jbc.RA120.015574

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