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PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain

Hsp70 proteins are a family of ancient and conserved chaperones. They play important roles in vital cellular processes, such as protein quality control and the stress response. Hsp70 proteins are a potential drug target for treatment of disease, particularly cancer. PES (2-phenylethynesulfonamide or...

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Detalles Bibliográficos
Autores principales:	Yang, Jie, Gong, Weibin, Wu, Si, Zhang, Hong, Perrett, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948744/ https://www.ncbi.nlm.nih.gov/pubmed/33835030 http://dx.doi.org/10.1074/jbc.RA120.015440

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