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Kidney-disease-associated variants of Apolipoprotein L1 show gain of function in cation channel activity
Variants in Apolipoprotein L1 (ApoL1) are known to be responsible for increased risk of some progressive kidney diseases among people of African ancestry. ApoL1 is an amphitropic protein that can insert into phospholipid membranes and confer anion- or cation-selective permeability to phospholipid me...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948812/ https://www.ncbi.nlm.nih.gov/pubmed/33380423 http://dx.doi.org/10.1074/jbc.RA120.013943 |