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Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot

Diabetic foot is challenging progressive disease which requires multisystemic control. Neuropathy, arteriopathy, and cellular responses should treated collaboratively. Despite all medical advances, diabetic foot can highly resulted with amputation and also re‐amputation can be required because of fa...

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Autores principales: Gülcü, Anıl, Etli, Mustafa, Karahan, Oğuz, Aslan, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948900/
https://www.ncbi.nlm.nih.gov/pubmed/33021061
http://dx.doi.org/10.1111/iwj.13491
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author Gülcü, Anıl
Etli, Mustafa
Karahan, Oğuz
Aslan, Ahmet
author_facet Gülcü, Anıl
Etli, Mustafa
Karahan, Oğuz
Aslan, Ahmet
author_sort Gülcü, Anıl
collection PubMed
description Diabetic foot is challenging progressive disease which requires multisystemic control. Neuropathy, arteriopathy, and cellular responses should treated collaboratively. Despite all medical advances, diabetic foot can highly resulted with amputation and also re‐amputation can be required because of failed wound healing. In this study, we aimed to investigate the relation between blood parameters and amputation events. Diabetic 323 patients include to the study who referred to orthopaedic clinic for amputation. Amputation levels (amputation levels phalanx, metatarsal, lisfranc, syme, below knee, knee‐disarticulation, above‐knee amputation) and re‐amputations recorded and compared with routine blood parameters. Re‐amputation was observed at 69 patients. The significant difference detected between lower albumin, higher HbA1c, higher CRP levels (P < 0.05) in regards to gross amputation levels, and increased wound depth. Furthermore, lower albumin levels and higher levels of WBC, HbA1c, CRP, and Creatinine were detected in re‐amputation levels. Especially, HbA1c, CRP, and Creatinine levels were found as upper bound of reference line for re‐amputation. The statistically optimal HbA1c cutoff point for diabetes was ≥7.05%, with a sensitivity of 86% and a specificity of 59%. In according to our results, simple blood parameters can be useful for observing the progress of amputation in diabetic foot. Particularly, lower albumin, and higher HbA1c, CRP, and Creatinine levels detected as related with poor prognosis. Besides, screening of HbA1c level seems to be highly sensitive for detecting of re‐amputation possibility.
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spelling pubmed-79489002021-07-02 Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot Gülcü, Anıl Etli, Mustafa Karahan, Oğuz Aslan, Ahmet Int Wound J Original Articles Diabetic foot is challenging progressive disease which requires multisystemic control. Neuropathy, arteriopathy, and cellular responses should treated collaboratively. Despite all medical advances, diabetic foot can highly resulted with amputation and also re‐amputation can be required because of failed wound healing. In this study, we aimed to investigate the relation between blood parameters and amputation events. Diabetic 323 patients include to the study who referred to orthopaedic clinic for amputation. Amputation levels (amputation levels phalanx, metatarsal, lisfranc, syme, below knee, knee‐disarticulation, above‐knee amputation) and re‐amputations recorded and compared with routine blood parameters. Re‐amputation was observed at 69 patients. The significant difference detected between lower albumin, higher HbA1c, higher CRP levels (P < 0.05) in regards to gross amputation levels, and increased wound depth. Furthermore, lower albumin levels and higher levels of WBC, HbA1c, CRP, and Creatinine were detected in re‐amputation levels. Especially, HbA1c, CRP, and Creatinine levels were found as upper bound of reference line for re‐amputation. The statistically optimal HbA1c cutoff point for diabetes was ≥7.05%, with a sensitivity of 86% and a specificity of 59%. In according to our results, simple blood parameters can be useful for observing the progress of amputation in diabetic foot. Particularly, lower albumin, and higher HbA1c, CRP, and Creatinine levels detected as related with poor prognosis. Besides, screening of HbA1c level seems to be highly sensitive for detecting of re‐amputation possibility. Blackwell Publishing Ltd 2020-10-05 /pmc/articles/PMC7948900/ /pubmed/33021061 http://dx.doi.org/10.1111/iwj.13491 Text en © 2020 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Gülcü, Anıl
Etli, Mustafa
Karahan, Oğuz
Aslan, Ahmet
Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot
title Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot
title_full Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot
title_fullStr Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot
title_full_unstemmed Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot
title_short Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot
title_sort analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948900/
https://www.ncbi.nlm.nih.gov/pubmed/33021061
http://dx.doi.org/10.1111/iwj.13491
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