Molecular dynamics approach to identification of new OGG1 cancer-associated somatic variants with impaired activity

DNA of living cells is always exposed to damaging factors. To counteract the consequences of DNA lesions, cells have evolved several DNA repair systems, among which base excision repair is one of the most important systems. Many currently used antitumor drugs act by damaging DNA, and DNA repair ofte...

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Detalles Bibliográficos
Autores principales: Popov, Aleksandr V., Endutkin, Anton V., Yatsenko, Darya D., Yudkina, Anna V., Barmatov, Alexander E., Makasheva, Kristina A., Raspopova, Darya Yu., Diatlova, Evgeniia A., Zharkov, Dmitry O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948927/
https://www.ncbi.nlm.nih.gov/pubmed/33361155
http://dx.doi.org/10.1074/jbc.RA120.014455

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