Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) remains the deadliest pathogenic bacteria worldwide. The search for new antibiotics to treat drug-sensitive as well as drug-resistant tuberculosis has become a priority. The essential enzyme phenylalanyl-tRNA synthetase (PheRS) is an antibacterial drug target because...

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Detalles Bibliográficos
Autores principales: Wang, Heng, Xu, Min, Engelhart, Curtis A., Zhang, Xi, Yan, Baohua, Pan, Miaomiao, Xu, Yuanyuan, Fan, Shilong, Liu, Renhe, Xu, Lan, Hua, Lan, Schnappinger, Dirk, Chen, Shawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948948/
https://www.ncbi.nlm.nih.gov/pubmed/33837735
http://dx.doi.org/10.1016/j.jbc.2021.100257

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