Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity

Acetaminophen (APAP)-induced liver necrosis is a form of regulated cell death (RCD) in which APAP activates the mitogen-activated protein kinases (MAPKs) and specifically the c-Jun-N-terminal kinase (JNK) pathway, leading to necrotic cell death. Previously, we have shown that receptor interacting pr...

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Detalles Bibliográficos
Autores principales: Iorga, Andrea, Donovan, Katherine, Shojaie, Layla, Johnson, Heather, Kwok, Janet, Suda, Jo, Lee, Brian T., Aghajan, Mariam, Shao, Ling, Liu, Zhang-Xu, Dara, Lily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948960/
https://www.ncbi.nlm.nih.gov/pubmed/33460648
http://dx.doi.org/10.1016/j.jbc.2021.100300

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