The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis

Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear protein that is activated by binding to DNA lesions and catalyzes poly(ADP-ribosyl)ation of nuclear acceptor proteins, including PARP1 itself, to recruit DNA repair machinery to DNA lesions. When excessive DNA damage occurs, poly(ADP-ribose) (PAR) p...

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Detalles Bibliográficos
Autores principales: Mashimo, Masato, Onishi, Mayu, Uno, Arina, Tanimichi, Akari, Nobeyama, Akari, Mori, Mana, Yamada, Sayaka, Negi, Shigeru, Bu, Xiangning, Kato, Jiro, Moss, Joel, Sanada, Noriko, Kizu, Ryoichi, Fujii, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948984/
https://www.ncbi.nlm.nih.gov/pubmed/33168626
http://dx.doi.org/10.1074/jbc.RA120.014479

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