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Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

The transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) regulates the expression of genes involved in antioxidant defenses to modulate fundamental cellular processes such as mitochondrial function and GSH metabolism. Previous reports proposed that mitochondrial reactive oxygen sp...

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Detalles Bibliográficos
Autores principales:	Cvetko, Filip, Caldwell, Stuart T., Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C., Dinkova-Kostova, Albena T., Murphy, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948991/ https://www.ncbi.nlm.nih.gov/pubmed/33298526 http://dx.doi.org/10.1074/jbc.RA120.016551

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