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Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles
Protein synthesis is an energetically costly cellular activity. It is therefore important that the process of mRNA translation remains in excellent synchrony with cellular metabolism and its energy reserves. Unregulated translation could lead to the production of incomplete, mistranslated, or misfol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949028/ https://www.ncbi.nlm.nih.gov/pubmed/33199376 http://dx.doi.org/10.1074/jbc.REV120.011985 |
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author | Shetty, Sunil Varshney, Umesh |
author_facet | Shetty, Sunil Varshney, Umesh |
author_sort | Shetty, Sunil |
collection | PubMed |
description | Protein synthesis is an energetically costly cellular activity. It is therefore important that the process of mRNA translation remains in excellent synchrony with cellular metabolism and its energy reserves. Unregulated translation could lead to the production of incomplete, mistranslated, or misfolded proteins, squandering the energy needed for cellular sustenance and causing cytotoxicity. One-carbon metabolism (OCM), an integral part of cellular intermediary metabolism, produces a number of one-carbon unit intermediates (formyl, methylene, methenyl, methyl). These OCM intermediates are required for the production of amino acids such as methionine and other biomolecules such as purines, thymidylate, and redox regulators. In this review, we discuss how OCM impacts the translation apparatus (composed of ribosome, tRNA, mRNA, and translation factors) and regulates crucial steps in protein synthesis. More specifically, we address how the OCM metabolites regulate the fidelity and rate of translation initiation in bacteria and eukaryotic organelles such as mitochondria. Modulation of the fidelity of translation initiation by OCM opens new avenues to understand alternative translation mechanisms involved in stress tolerance and drug resistance. |
format | Online Article Text |
id | pubmed-7949028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-79490282021-03-19 Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles Shetty, Sunil Varshney, Umesh J Biol Chem JBC Reviews Protein synthesis is an energetically costly cellular activity. It is therefore important that the process of mRNA translation remains in excellent synchrony with cellular metabolism and its energy reserves. Unregulated translation could lead to the production of incomplete, mistranslated, or misfolded proteins, squandering the energy needed for cellular sustenance and causing cytotoxicity. One-carbon metabolism (OCM), an integral part of cellular intermediary metabolism, produces a number of one-carbon unit intermediates (formyl, methylene, methenyl, methyl). These OCM intermediates are required for the production of amino acids such as methionine and other biomolecules such as purines, thymidylate, and redox regulators. In this review, we discuss how OCM impacts the translation apparatus (composed of ribosome, tRNA, mRNA, and translation factors) and regulates crucial steps in protein synthesis. More specifically, we address how the OCM metabolites regulate the fidelity and rate of translation initiation in bacteria and eukaryotic organelles such as mitochondria. Modulation of the fidelity of translation initiation by OCM opens new avenues to understand alternative translation mechanisms involved in stress tolerance and drug resistance. American Society for Biochemistry and Molecular Biology 2020-11-21 /pmc/articles/PMC7949028/ /pubmed/33199376 http://dx.doi.org/10.1074/jbc.REV120.011985 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | JBC Reviews Shetty, Sunil Varshney, Umesh Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles |
title | Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles |
title_full | Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles |
title_fullStr | Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles |
title_full_unstemmed | Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles |
title_short | Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles |
title_sort | regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles |
topic | JBC Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949028/ https://www.ncbi.nlm.nih.gov/pubmed/33199376 http://dx.doi.org/10.1074/jbc.REV120.011985 |
work_keys_str_mv | AT shettysunil regulationoftranslationbyonecarbonmetabolisminbacteriaandeukaryoticorganelles AT varshneyumesh regulationoftranslationbyonecarbonmetabolisminbacteriaandeukaryoticorganelles |