Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis

Normal human cells can either synthesize cholesterol or take it up from lipoproteins to meet their metabolic requirements. In some malignant cells, de novo cholesterol synthesis genes are transcriptionally silent or mutated, meaning that cholesterol uptake from lipoproteins is required for survival....

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Detalles Bibliográficos
Autores principales: Rink, Jonathan S., Lin, Adam Yuh, McMahon, Kaylin M., Calvert, Andrea E., Yang, Shuo, Taxter, Tim, Moreira, Jonathan, Chadburn, Amy, Behdad, Amir, Karmali, Reem, Thaxton, C. Shad, Gordon, Leo I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949030/
https://www.ncbi.nlm.nih.gov/pubmed/33208460
http://dx.doi.org/10.1074/jbc.RA120.014888

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