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Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance

Class A serine β-lactamases (SBLs) are key antibiotic resistance determinants in Gram-negative bacteria. SBLs neutralize β-lactams via a hydrolytically labile covalent acyl–enzyme intermediate. Klebsiella pneumoniae carbapenemase (KPC) is a widespread SBL that hydrolyzes carbapenems, the most potent...

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Detalles Bibliográficos
Autores principales:	Tooke, Catherine L., Hinchliffe, Philip, Bonomo, Robert A., Schofield, Christopher J., Mulholland, Adrian J., Spencer, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949053/ https://www.ncbi.nlm.nih.gov/pubmed/33257320 http://dx.doi.org/10.1074/jbc.RA120.016461

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