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TNF-α–mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer’s disease pathology in young Trem2(R47H) rats

Alzheimer’s disease (AD) is a neurodegenerative dementia associated with deposition of amyloid plaques and neurofibrillary tangles, formed by amyloid β (Aβ) peptides and phosphor-tau, respectively, in the central nervous system. Approximately 2% of AD cases are due to familial AD (FAD); ∼98% of case...

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Detalles Bibliográficos
Autores principales:	Ren, Siqiang, Breuillaud, Lionel, Yao, Wen, Yin, Tao, Norris, Kelly A., Zehntner, Simone P., D’Adamio, Luciano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949092/ https://www.ncbi.nlm.nih.gov/pubmed/33434745 http://dx.doi.org/10.1074/jbc.RA120.016395

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