The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14

For most G protein–coupled receptors, the third intracellular loop (IL3) and carboxy-terminal tail (CT) are sites for G protein–coupled receptor kinase (GRK)–mediated phosphorylation, leading to β-arrestin binding and agonist-specific desensitization. These regions of bitter taste receptors (TAS2Rs)...

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Detalles Bibliográficos
Autores principales: Kim, Donghwa, Castaño, Maria, Lujan, Lauren K., Woo, Jung A., Liggett, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949105/
https://www.ncbi.nlm.nih.gov/pubmed/33465377
http://dx.doi.org/10.1074/jbc.RA120.016056

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