Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na(+) in ion-coupled drug efflux

In both prokaryotes and eukaryotes, multidrug and toxic-compound extrusion (MATE) transporters catalyze the efflux of a broad range of cytotoxic compounds, including human-made antibiotics and anticancer drugs. MATEs are secondary-active antiporters, i.e., their drug-efflux activity is coupled to, a...

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Detalles Bibliográficos
Autores principales: Castellano, Steven, Claxton, Derek P., Ficici, Emel, Kusakizako, Tsukasa, Stix, Robyn, Zhou, Wenchang, Nureki, Osamu, Mchaourab, Hassane S., Faraldo-Gómez, José D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949106/
https://www.ncbi.nlm.nih.gov/pubmed/33837745
http://dx.doi.org/10.1016/j.jbc.2021.100262

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