Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation

Medulloblastoma is the most common pediatric brain cancer, and sequencing studies identified frequent mutations in DDX3X, a DEAD-box RNA helicase primarily implicated in translation. Forty-two different sites were identified, suggesting that the functional effects of the mutations are complex. To in...

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Detalles Bibliográficos
Autores principales: Brown, Nicolette P., Vergara, Ashley M., Whelan, Alisha B., Guerra, Paolo, Bolger, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949108/
https://www.ncbi.nlm.nih.gov/pubmed/33460649
http://dx.doi.org/10.1016/j.jbc.2021.100296

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