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Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis

The serine protease inhibitor Kazal type 1 (SPINK1) protects the pancreas from intrapancreatic trypsin activation that can lead to pancreatitis. Loss-of-function genetic variants of SPINK1 increase the risk for chronic pancreatitis, often by diminishing inhibitor expression or secretion. Variants th...

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Detalles Bibliográficos
Autores principales:	Szabó, András, Toldi, Vanda, Gazda, Lívia Diána, Demcsák, Alexandra, Tőzsér, József, Sahin-Tóth, Miklós
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949130/ https://www.ncbi.nlm.nih.gov/pubmed/33515547 http://dx.doi.org/10.1016/j.jbc.2021.100343

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