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Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer

Topoisomerase IIβ-binding protein 1 (TopBP1) is involved in cellular replication among other functions and is known to activate ATR/Chk1 during replicative stress. TopBP1 is also expressed at high levels in many cancers. However, the impact of TopBP1 overexpression on ATR/Chk1 activation and cancer...

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Detalles Bibliográficos
Autores principales:	Liu, Kang, Graves, Joshua D., Lin, Fang-Tsyr, Lin, Weei-Chin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949146/ https://www.ncbi.nlm.nih.gov/pubmed/33556369 http://dx.doi.org/10.1016/j.jbc.2021.100382

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