The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer

The recent discovery of the cancer-associated E76K mutation in histone H2B (H2BE76-to-K) in several types of cancers revealed a new class of oncohistone. H2BE76K weakens the stability of histone octamers, alters gene expression, and promotes colony formation. However, the mechanism linking the H2BE7...

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Detalles Bibliográficos
Autores principales: Kang, Tze Zhen Evangeline, Zhu, Lina, Yang, Du, Ding, Dongbo, Zhu, Xiaoxuan, Wan, Yi Ching Esther, Liu, Jiaxian, Ramakrishnan, Saravanan, Chan, Landon Long, Chan, Siu Yuen, Wang, Xin, Gan, Haiyun, Han, Junhong, Ishibashi, Toyotaka, Li, Qing, Chan, Kui Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949156/
https://www.ncbi.nlm.nih.gov/pubmed/33548228
http://dx.doi.org/10.1016/j.jbc.2021.100374

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