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Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer

During the integration step, human immunodeficiency virus type 1 integrase (IN) interacts with viral DNA and the cellular cofactor LEDGF/p75 to effectively integrate the reverse transcript into the host chromatin. Allosteric human immunodeficiency virus type 1 integrase inhibitors (ALLINIs) are a ne...

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Detalles Bibliográficos
Autores principales:	Sun, Jian, Patel, Krunal, Hume, Jared, Pigza, Julie A., Donahue, Matthew G., Kessl, Jacques J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949159/ https://www.ncbi.nlm.nih.gov/pubmed/33539919 http://dx.doi.org/10.1016/j.jbc.2021.100363

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