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The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial

INTRODUCTION: Dentin hypersensitivity (DH) is defined as high sensitivity of the vital dentin when exposed to thermal, chemical or tactile stimuli. Two mechanisms are required for the occurrence of DH: (1) the dentin must be exposed and (2) the dentinal tubules must be open and connected to the pulp...

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Autores principales: Sobral, Ana Paula Taboada, Santos, Elaine Marcilio, Aranha, Ana Cecilia, Soares, Paulo Vinícius, Moriyama, Caroline Moraes, Gonçalves, Marcela Leticia Leal, Ribeiro, Rodrigo Alves, Motta, Lara Jansiski, Horliana, Anna Carolina Ratto Tempestini, Fernandes, Kristianne Porta Santos, Mesquita-Ferrari, Raquel Agnelli, Bussadori, Sandra Kalil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949385/
https://www.ncbi.nlm.nih.gov/pubmed/33692185
http://dx.doi.org/10.1136/bmjopen-2020-044653
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author Sobral, Ana Paula Taboada
Santos, Elaine Marcilio
Aranha, Ana Cecilia
Soares, Paulo Vinícius
Moriyama, Caroline Moraes
Gonçalves, Marcela Leticia Leal
Ribeiro, Rodrigo Alves
Motta, Lara Jansiski
Horliana, Anna Carolina Ratto Tempestini
Fernandes, Kristianne Porta Santos
Mesquita-Ferrari, Raquel Agnelli
Bussadori, Sandra Kalil
author_facet Sobral, Ana Paula Taboada
Santos, Elaine Marcilio
Aranha, Ana Cecilia
Soares, Paulo Vinícius
Moriyama, Caroline Moraes
Gonçalves, Marcela Leticia Leal
Ribeiro, Rodrigo Alves
Motta, Lara Jansiski
Horliana, Anna Carolina Ratto Tempestini
Fernandes, Kristianne Porta Santos
Mesquita-Ferrari, Raquel Agnelli
Bussadori, Sandra Kalil
author_sort Sobral, Ana Paula Taboada
collection PubMed
description INTRODUCTION: Dentin hypersensitivity (DH) is defined as high sensitivity of the vital dentin when exposed to thermal, chemical or tactile stimuli. Two mechanisms are required for the occurrence of DH: (1) the dentin must be exposed and (2) the dentinal tubules must be open and connected to the pulp. Molar–incisor hypomineralisation (MIH) is a qualitative abnormality of a genetic origin that affects tooth enamel and, in most cases, is accompanied by DH. The control of tooth sensitivity is fundamental to the successful treatment of MIH. The aim of the proposed randomised, controlled, clinical trial is to evaluate the effectiveness of different protocols for the control of DH in patients with teeth affected by MIH. METHODS AND ANALYSIS: One hundred and forty patients who meet the inclusion criteria will be allocated to four groups. Group 1 will be the control group (placebo). In Group 2, sensitive teeth will be sealed with PermaSeal (Ultradent). In Group 3, sensitive teeth will receive low-level laser (LLL, AsGaAl) at a wavelength of 780 nm (Laser XT Therapy, DMC, São Carlos, Brazil). In Group 4, sensitive teeth will be treated with both LLL and PermaSeal (Ultradent). DH will be evaluated 15 min after the application of the treatments and the patients will be reevaluated 1 week, 1 month, 3 months and 6 months after the treatments. The primary outcome of this study is change in pain/sensitivity, when evaluated through a Visual Analogue Scale, to determine the effectiveness of the proposed treatments, as well as differences among the evaluation times for each proposed treatment. ETHICS AND DISSEMINATION: This protocol has been ethically approved by the local medical ethical committee (protocol number: 4.020.261). Results will be submitted to international peer-reviewed journals and presented at international conferences. TRIAL REGISTRATION NUMBER: NCT04407702.
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spelling pubmed-79493852021-03-28 The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial Sobral, Ana Paula Taboada Santos, Elaine Marcilio Aranha, Ana Cecilia Soares, Paulo Vinícius Moriyama, Caroline Moraes Gonçalves, Marcela Leticia Leal Ribeiro, Rodrigo Alves Motta, Lara Jansiski Horliana, Anna Carolina Ratto Tempestini Fernandes, Kristianne Porta Santos Mesquita-Ferrari, Raquel Agnelli Bussadori, Sandra Kalil BMJ Open Dentistry and Oral Medicine INTRODUCTION: Dentin hypersensitivity (DH) is defined as high sensitivity of the vital dentin when exposed to thermal, chemical or tactile stimuli. Two mechanisms are required for the occurrence of DH: (1) the dentin must be exposed and (2) the dentinal tubules must be open and connected to the pulp. Molar–incisor hypomineralisation (MIH) is a qualitative abnormality of a genetic origin that affects tooth enamel and, in most cases, is accompanied by DH. The control of tooth sensitivity is fundamental to the successful treatment of MIH. The aim of the proposed randomised, controlled, clinical trial is to evaluate the effectiveness of different protocols for the control of DH in patients with teeth affected by MIH. METHODS AND ANALYSIS: One hundred and forty patients who meet the inclusion criteria will be allocated to four groups. Group 1 will be the control group (placebo). In Group 2, sensitive teeth will be sealed with PermaSeal (Ultradent). In Group 3, sensitive teeth will receive low-level laser (LLL, AsGaAl) at a wavelength of 780 nm (Laser XT Therapy, DMC, São Carlos, Brazil). In Group 4, sensitive teeth will be treated with both LLL and PermaSeal (Ultradent). DH will be evaluated 15 min after the application of the treatments and the patients will be reevaluated 1 week, 1 month, 3 months and 6 months after the treatments. The primary outcome of this study is change in pain/sensitivity, when evaluated through a Visual Analogue Scale, to determine the effectiveness of the proposed treatments, as well as differences among the evaluation times for each proposed treatment. ETHICS AND DISSEMINATION: This protocol has been ethically approved by the local medical ethical committee (protocol number: 4.020.261). Results will be submitted to international peer-reviewed journals and presented at international conferences. TRIAL REGISTRATION NUMBER: NCT04407702. BMJ Publishing Group 2021-03-10 /pmc/articles/PMC7949385/ /pubmed/33692185 http://dx.doi.org/10.1136/bmjopen-2020-044653 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Dentistry and Oral Medicine
Sobral, Ana Paula Taboada
Santos, Elaine Marcilio
Aranha, Ana Cecilia
Soares, Paulo Vinícius
Moriyama, Caroline Moraes
Gonçalves, Marcela Leticia Leal
Ribeiro, Rodrigo Alves
Motta, Lara Jansiski
Horliana, Anna Carolina Ratto Tempestini
Fernandes, Kristianne Porta Santos
Mesquita-Ferrari, Raquel Agnelli
Bussadori, Sandra Kalil
The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial
title The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial
title_full The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial
title_fullStr The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial
title_full_unstemmed The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial
title_short The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial
title_sort control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial
topic Dentistry and Oral Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949385/
https://www.ncbi.nlm.nih.gov/pubmed/33692185
http://dx.doi.org/10.1136/bmjopen-2020-044653
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