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Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review

Negative pressure wound therapy (NPWT), which has been applied in various medical specialties to accelerate wound healing, has been the object of a few investigations. We explored the effectiveness of NPWT and the possibility of its inclusion in burn management guidelines. Randomised controlled tria...

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Autores principales: Lin, Dai‐Zhu, Kao, Yu‐Chien, Chen, Chiehfeng, Wang, Hsian‐Jenn, Chiu, Wen‐Kuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949461/
https://www.ncbi.nlm.nih.gov/pubmed/33236845
http://dx.doi.org/10.1111/iwj.13500
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author Lin, Dai‐Zhu
Kao, Yu‐Chien
Chen, Chiehfeng
Wang, Hsian‐Jenn
Chiu, Wen‐Kuan
author_facet Lin, Dai‐Zhu
Kao, Yu‐Chien
Chen, Chiehfeng
Wang, Hsian‐Jenn
Chiu, Wen‐Kuan
author_sort Lin, Dai‐Zhu
collection PubMed
description Negative pressure wound therapy (NPWT), which has been applied in various medical specialties to accelerate wound healing, has been the object of a few investigations. We explored the effectiveness of NPWT and the possibility of its inclusion in burn management guidelines. Randomised controlled trials comparing NPWT with non‐NPWT treatments for burn wounds were extracted from PubMed. For the risk of bias analysis, all included studies were evaluated according to the Cochrane risk of bias tool and the approaches outlined in the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) Handbook. Outcomes such as graft take rate in the first week, infection rate, and overall complication rate were analysed. Six studies that included a total of 701 patients met our inclusion criteria. Qualitative analysis revealed that the NPWT group had a significantly better overall graft rate in the first week (P = 0.001) and a significantly lower infection rate (P = 0.04). No significant difference in the overall complication rate was found. Our results indicate that NPWT is a safe method for stimulating healing and lowering the infection rate of burn wounds. NPWT can be part of general burn management, and its incorporation into burn treatment guidelines is recommended.
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spelling pubmed-79494612021-07-02 Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review Lin, Dai‐Zhu Kao, Yu‐Chien Chen, Chiehfeng Wang, Hsian‐Jenn Chiu, Wen‐Kuan Int Wound J Original Articles Negative pressure wound therapy (NPWT), which has been applied in various medical specialties to accelerate wound healing, has been the object of a few investigations. We explored the effectiveness of NPWT and the possibility of its inclusion in burn management guidelines. Randomised controlled trials comparing NPWT with non‐NPWT treatments for burn wounds were extracted from PubMed. For the risk of bias analysis, all included studies were evaluated according to the Cochrane risk of bias tool and the approaches outlined in the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) Handbook. Outcomes such as graft take rate in the first week, infection rate, and overall complication rate were analysed. Six studies that included a total of 701 patients met our inclusion criteria. Qualitative analysis revealed that the NPWT group had a significantly better overall graft rate in the first week (P = 0.001) and a significantly lower infection rate (P = 0.04). No significant difference in the overall complication rate was found. Our results indicate that NPWT is a safe method for stimulating healing and lowering the infection rate of burn wounds. NPWT can be part of general burn management, and its incorporation into burn treatment guidelines is recommended. Blackwell Publishing Ltd 2020-11-25 /pmc/articles/PMC7949461/ /pubmed/33236845 http://dx.doi.org/10.1111/iwj.13500 Text en © 2020 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Lin, Dai‐Zhu
Kao, Yu‐Chien
Chen, Chiehfeng
Wang, Hsian‐Jenn
Chiu, Wen‐Kuan
Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review
title Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review
title_full Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review
title_fullStr Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review
title_full_unstemmed Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review
title_short Negative pressure wound therapy for burn patients: A meta‐analysis and systematic review
title_sort negative pressure wound therapy for burn patients: a meta‐analysis and systematic review
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949461/
https://www.ncbi.nlm.nih.gov/pubmed/33236845
http://dx.doi.org/10.1111/iwj.13500
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