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Therapeutic potential of curcumin in diabetic retinopathy (Review)

Diabetic retinopathy (DR) is a type of retinal microangiopathy caused by diabetes mellitus. It has become the leading cause of blindness among working individuals worldwide. DR is becoming increasingly common among younger diabetic patients and there is a need for lifelong treatment. The pathogenic...

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Autores principales: Yang, Jian, Miao, Xiao, Yang, Feng-Juan, Cao, Jin-Feng, Liu, Xin, Fu, Jin-Ling, Su, Guan-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949626/
https://www.ncbi.nlm.nih.gov/pubmed/33693955
http://dx.doi.org/10.3892/ijmm.2021.4908
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author Yang, Jian
Miao, Xiao
Yang, Feng-Juan
Cao, Jin-Feng
Liu, Xin
Fu, Jin-Ling
Su, Guan-Fang
author_facet Yang, Jian
Miao, Xiao
Yang, Feng-Juan
Cao, Jin-Feng
Liu, Xin
Fu, Jin-Ling
Su, Guan-Fang
author_sort Yang, Jian
collection PubMed
description Diabetic retinopathy (DR) is a type of retinal microangiopathy caused by diabetes mellitus. It has become the leading cause of blindness among working individuals worldwide. DR is becoming increasingly common among younger diabetic patients and there is a need for lifelong treatment. The pathogenic mechanisms of DR are influenced by a number of factors, such as hyperglycemia, hyperlipidemia, inflammatory response and oxidative stress, among others. Currently, the treatment methods for DR mainly include retinal photocoagulation, vitrectomy, or anti-vascular endothelial growth factor (VEGF) therapy. However, these methods have some disadvantages and limitations. Therefore, it is a matter of great interest and urgency to discover drugs that can target the pathogenesis of DR. Since ancient times, traditional Chinese medicine practitioners have accumulated extensive experiences in the use of Chinese herbal medicine for the prevention and treatment of diseases. In the theory of traditional Chinese medicine, curcumin has the effects of promoting blood circulation and relieving pain. A number of studies have also demonstrated that curcumin has multiple biological activities, including exerting anti-apoptotic, anti-inflammatory, antioxidant and antitumor properties. In recent years, studies have also confirmed that curcumin can prevent a variety of diabetic complications, including diabetic nephropathy (DN). However, the preventive and curative effects of curcumin on DR and its mechanisms of action have not yet been fully elucidated. The present review aimed to explore the therapeutic potential of curcumin in diabetes mellitus and DR.
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spelling pubmed-79496262021-03-22 Therapeutic potential of curcumin in diabetic retinopathy (Review) Yang, Jian Miao, Xiao Yang, Feng-Juan Cao, Jin-Feng Liu, Xin Fu, Jin-Ling Su, Guan-Fang Int J Mol Med Articles Diabetic retinopathy (DR) is a type of retinal microangiopathy caused by diabetes mellitus. It has become the leading cause of blindness among working individuals worldwide. DR is becoming increasingly common among younger diabetic patients and there is a need for lifelong treatment. The pathogenic mechanisms of DR are influenced by a number of factors, such as hyperglycemia, hyperlipidemia, inflammatory response and oxidative stress, among others. Currently, the treatment methods for DR mainly include retinal photocoagulation, vitrectomy, or anti-vascular endothelial growth factor (VEGF) therapy. However, these methods have some disadvantages and limitations. Therefore, it is a matter of great interest and urgency to discover drugs that can target the pathogenesis of DR. Since ancient times, traditional Chinese medicine practitioners have accumulated extensive experiences in the use of Chinese herbal medicine for the prevention and treatment of diseases. In the theory of traditional Chinese medicine, curcumin has the effects of promoting blood circulation and relieving pain. A number of studies have also demonstrated that curcumin has multiple biological activities, including exerting anti-apoptotic, anti-inflammatory, antioxidant and antitumor properties. In recent years, studies have also confirmed that curcumin can prevent a variety of diabetic complications, including diabetic nephropathy (DN). However, the preventive and curative effects of curcumin on DR and its mechanisms of action have not yet been fully elucidated. The present review aimed to explore the therapeutic potential of curcumin in diabetes mellitus and DR. D.A. Spandidos 2021-05 2021-03-04 /pmc/articles/PMC7949626/ /pubmed/33693955 http://dx.doi.org/10.3892/ijmm.2021.4908 Text en Copyright: © Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yang, Jian
Miao, Xiao
Yang, Feng-Juan
Cao, Jin-Feng
Liu, Xin
Fu, Jin-Ling
Su, Guan-Fang
Therapeutic potential of curcumin in diabetic retinopathy (Review)
title Therapeutic potential of curcumin in diabetic retinopathy (Review)
title_full Therapeutic potential of curcumin in diabetic retinopathy (Review)
title_fullStr Therapeutic potential of curcumin in diabetic retinopathy (Review)
title_full_unstemmed Therapeutic potential of curcumin in diabetic retinopathy (Review)
title_short Therapeutic potential of curcumin in diabetic retinopathy (Review)
title_sort therapeutic potential of curcumin in diabetic retinopathy (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949626/
https://www.ncbi.nlm.nih.gov/pubmed/33693955
http://dx.doi.org/10.3892/ijmm.2021.4908
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