The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases

Cullin RING E3 ligases (CRLs) ubiquitylate hundreds of important cellular substrates. Here we have assembled and purified the Ankyrin repeat and SOCS Box protein 9 CUL5 RBX2 ligase (ASB9-CRL) in vitro and show how it ubiquitylates one of its substrates, CKB. CRLs occasionally collaborate with RING b...

Descripción completa

Detalles Bibliográficos
Autores principales: Lumpkin, Ryan J., Ahmad, Alla S., Blake, Rachel, Condon, Christopher J., Komives, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950132/
https://www.ncbi.nlm.nih.gov/pubmed/33268465
http://dx.doi.org/10.1074/mcp.RA120.002414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950132/
https://www.ncbi.nlm.nih.gov/pubmed/33268465
http://dx.doi.org/10.1074/mcp.RA120.002414

Ejemplares similares