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A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells

In this study, we investigated the effect of a short deletion in the DNA-binding domain of STAT3 (STAT3(del)) on the transcriptional activation of STAT3 target genes and its relationship with colon carcinogenesis. We used the CRISPR-CAS9 gene editing system to delete a short sequence encoding amino...

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Detalles Bibliográficos
Autores principales:	Xiong, Yi-Jia, Liu, Dong-Yang, Shen, Rong-Rong, Xiong, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950243/ https://www.ncbi.nlm.nih.gov/pubmed/33535185 http://dx.doi.org/10.18632/aging.202439

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