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Aging and rejuvenation - a modular epigenome model
The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understandin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950254/ https://www.ncbi.nlm.nih.gov/pubmed/33627519 http://dx.doi.org/10.18632/aging.202712 |
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author | Chiavellini, Priscila Canatelli-Mallat, Martina Lehmann, Marianne Gallardo, Maria D. Herenu, Claudia B. Cordeiro, Jose L. Clement, James Goya, Rodolfo G. |
author_facet | Chiavellini, Priscila Canatelli-Mallat, Martina Lehmann, Marianne Gallardo, Maria D. Herenu, Claudia B. Cordeiro, Jose L. Clement, James Goya, Rodolfo G. |
author_sort | Chiavellini, Priscila |
collection | PubMed |
description | The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging. |
format | Online Article Text |
id | pubmed-7950254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-79502542021-03-23 Aging and rejuvenation - a modular epigenome model Chiavellini, Priscila Canatelli-Mallat, Martina Lehmann, Marianne Gallardo, Maria D. Herenu, Claudia B. Cordeiro, Jose L. Clement, James Goya, Rodolfo G. Aging (Albany NY) Research Perspective The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging. Impact Journals 2021-02-24 /pmc/articles/PMC7950254/ /pubmed/33627519 http://dx.doi.org/10.18632/aging.202712 Text en Copyright: © 2021 Chiavellini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Perspective Chiavellini, Priscila Canatelli-Mallat, Martina Lehmann, Marianne Gallardo, Maria D. Herenu, Claudia B. Cordeiro, Jose L. Clement, James Goya, Rodolfo G. Aging and rejuvenation - a modular epigenome model |
title | Aging and rejuvenation - a modular epigenome model |
title_full | Aging and rejuvenation - a modular epigenome model |
title_fullStr | Aging and rejuvenation - a modular epigenome model |
title_full_unstemmed | Aging and rejuvenation - a modular epigenome model |
title_short | Aging and rejuvenation - a modular epigenome model |
title_sort | aging and rejuvenation - a modular epigenome model |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950254/ https://www.ncbi.nlm.nih.gov/pubmed/33627519 http://dx.doi.org/10.18632/aging.202712 |
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