Blockade of Indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression

Indoleamine 2, 3-dioxygenase 1 (IDO1) has been implicated in the pathogenesis of depression, though its molecular mechanism is still poorly understood. We investigated the molecular mechanism of IDO1 in depression by using the chronic unpredictable mild stress (CUMS) model in Ido1(-/-) mice and WT m...

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Detalles Bibliográficos
Autores principales: Gao, Lei, Gao, Tingting, Zeng, Ting, Huang, Peng, Wong, Nai-Kei, Dong, Zhaoyang, Li, Yunjia, Deng, Guanghui, Wu, Zhiyong, Lv, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950278/
https://www.ncbi.nlm.nih.gov/pubmed/33591947
http://dx.doi.org/10.18632/aging.202511

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