Cargando…
Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes
Senescent cells produce chronic inflammation that contributes to the diseases and debilities of aging. How this process is orchestrated in epithelial cells, the origin of human carcinomas, is poorly understood. We used human normal oral keratinocytes (NOKs) to elucidate senescence programs in a prot...
Autores principales: | Schwartz, Rachael E., Shokhirev, Maxim N., Andrade, Leonardo R., Gutkind, J. Silvio, Iglesias-Bartolome, Ramiro, Shadel, Gerald S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950289/ https://www.ncbi.nlm.nih.gov/pubmed/33601339 http://dx.doi.org/10.18632/aging.202658 |
Ejemplares similares
-
A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA(+) oral cancers
por: Yamaguchi, Kosuke, et al.
Publicado: (2016) -
Exploiting the mTOR paradox for disease prevention
por: Iglesias-Bartolome, Ramiro, et al.
Publicado: (2012) -
Gene expression signatures of human senescent corneal and conjunctival epithelial cells
por: Kitazawa, Koji, et al.
Publicado: (2023) -
GRSF1 suppresses cell senescence
por: Noh, Ji Heon, et al.
Publicado: (2018) -
Acid ceramidase promotes senescent cell survival
por: Munk, Rachel, et al.
Publicado: (2021)