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CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract

Ultraviolet B (UVB) irradiation could trigger DNA double-strand breaks (DDSBs) and senescence in lens epithelial cells (LECs), thus inducing age-related cortical cataract (ARCC) formation. Cell-cycle irreversible arrest induced by DDSBs depended on excessive activation of ataxia-telangiectasia mutat...

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Detalles Bibliográficos
Autores principales:	Liu, Junliang, Zhang, Jinling, Zhang, Guowei, Zhou, Tianqiu, Zou, Xi, Guan, Huaijin, Wang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950295/ https://www.ncbi.nlm.nih.gov/pubmed/33508783 http://dx.doi.org/10.18632/aging.202470

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