ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation by HLA class I at the cell surface, which suggests that ERAP2-dependent pe...

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Detalles Bibliográficos
Autores principales: Venema, Wouter J., Hiddingh, Sanne, de Boer, Joke H., Claas, Frans H. J., Mulder, Arend, den Hollander, Anneke I., Stratikos, Efstratios, Sarkizova, Siranush, van der Veken, Lars T., Janssen, George M. C., van Veelen, Peter A., Kuiper, Jonas J. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950316/
https://www.ncbi.nlm.nih.gov/pubmed/33717175
http://dx.doi.org/10.3389/fimmu.2021.634441

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