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Enhanced accessibility and hydrophobicity of amyloidogenic intermediates of the β2-microglobulin D76N mutant revealed by high-pressure experiments
β2-Microglobulin (β2m) is the causative protein of dialysis-related amyloidosis. Its unfolding mainly proceeds along the pathway of N(C) →U(C) ⇄ U(T), whereas refolding follows the U(T) → I(T) (→N(T)) →N(C) pathway, in which N, I, and U are the native, intermediate, and unfolded states, respectively...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950326/ https://www.ncbi.nlm.nih.gov/pubmed/33508321 http://dx.doi.org/10.1016/j.jbc.2021.100333 |