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Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review
PURPOSE: Currently, there is an increasing interest regarding the impact of COVID-19 on the thyroid function. As several recent reports have described the onset of thyroid dysfunction in patients diagnosed with COVID-19, we performed a systematic review to assess the prevalence of thyroid dysfunctio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950424/ https://www.ncbi.nlm.nih.gov/pubmed/33728279 http://dx.doi.org/10.1007/s40336-021-00419-y |
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author | Giovanella, Luca Ruggeri, Rosaria M. Ovčariček, Petra Petranović Campenni, Alfredo Treglia, Giorgio Deandreis, Desiree |
author_facet | Giovanella, Luca Ruggeri, Rosaria M. Ovčariček, Petra Petranović Campenni, Alfredo Treglia, Giorgio Deandreis, Desiree |
author_sort | Giovanella, Luca |
collection | PubMed |
description | PURPOSE: Currently, there is an increasing interest regarding the impact of COVID-19 on the thyroid function. As several recent reports have described the onset of thyroid dysfunction in patients diagnosed with COVID-19, we performed a systematic review to assess the prevalence of thyroid dysfunction in patients with COVID-19 as this information could be clinically relevant for the management of these patients. METHODS: A comprehensive computer literature search using PubMed/Medline and Cochrane databases was performed until November 14, 2020 to search original articles evaluating thyroid dysfunction in COVID-19 patients. Information about thyroid dysfunction assessed by thyroid function test was retrieved by the eligible articles. Qualitative analysis (systematic review) only was performed whether a significant heterogeneity of data was detected. RESULTS: Seven studies including 1237 patients with COVID-19 were included. A significant heterogeneity across the studies was found. Most COVID-19 patients were euthyroid with TSH levels in the normal range (from 44 to 94% of the COVID-19 patients assessed in the included studies). The prevalence of thyroid dysfunction in COVID-19 patients (defined as abnormal thyroid function tests) largely varies among the included studies between 13 and 64% of COVID-19 patients as well as clinical presentation. A positive correlation between thyroid dysfunction and clinical severity of COVID-19 was reported. CONCLUSION: Literature data show that thyroid dysfunction is present in a significant percentage of patients with COVID-19. Assessment of thyroid function may be considered in symptomatic COVID-19 patients to have a baseline before introducing thyroid-interfering drugs and those requiring high-intensity care. Further, well-designed studies are needed to better elucidate the impact of COVID-19 on thyroid function and inform thyroid function testing and thyroid dysfunction management in COVID-19 patients. |
format | Online Article Text |
id | pubmed-7950424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-79504242021-03-12 Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review Giovanella, Luca Ruggeri, Rosaria M. Ovčariček, Petra Petranović Campenni, Alfredo Treglia, Giorgio Deandreis, Desiree Clin Transl Imaging Systematic Review PURPOSE: Currently, there is an increasing interest regarding the impact of COVID-19 on the thyroid function. As several recent reports have described the onset of thyroid dysfunction in patients diagnosed with COVID-19, we performed a systematic review to assess the prevalence of thyroid dysfunction in patients with COVID-19 as this information could be clinically relevant for the management of these patients. METHODS: A comprehensive computer literature search using PubMed/Medline and Cochrane databases was performed until November 14, 2020 to search original articles evaluating thyroid dysfunction in COVID-19 patients. Information about thyroid dysfunction assessed by thyroid function test was retrieved by the eligible articles. Qualitative analysis (systematic review) only was performed whether a significant heterogeneity of data was detected. RESULTS: Seven studies including 1237 patients with COVID-19 were included. A significant heterogeneity across the studies was found. Most COVID-19 patients were euthyroid with TSH levels in the normal range (from 44 to 94% of the COVID-19 patients assessed in the included studies). The prevalence of thyroid dysfunction in COVID-19 patients (defined as abnormal thyroid function tests) largely varies among the included studies between 13 and 64% of COVID-19 patients as well as clinical presentation. A positive correlation between thyroid dysfunction and clinical severity of COVID-19 was reported. CONCLUSION: Literature data show that thyroid dysfunction is present in a significant percentage of patients with COVID-19. Assessment of thyroid function may be considered in symptomatic COVID-19 patients to have a baseline before introducing thyroid-interfering drugs and those requiring high-intensity care. Further, well-designed studies are needed to better elucidate the impact of COVID-19 on thyroid function and inform thyroid function testing and thyroid dysfunction management in COVID-19 patients. Springer International Publishing 2021-03-11 2021 /pmc/articles/PMC7950424/ /pubmed/33728279 http://dx.doi.org/10.1007/s40336-021-00419-y Text en © Italian Association of Nuclear Medicine and Molecular Imaging 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Systematic Review Giovanella, Luca Ruggeri, Rosaria M. Ovčariček, Petra Petranović Campenni, Alfredo Treglia, Giorgio Deandreis, Desiree Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review |
title | Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review |
title_full | Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review |
title_fullStr | Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review |
title_full_unstemmed | Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review |
title_short | Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review |
title_sort | prevalence of thyroid dysfunction in patients with covid-19: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950424/ https://www.ncbi.nlm.nih.gov/pubmed/33728279 http://dx.doi.org/10.1007/s40336-021-00419-y |
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