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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
The myeloid tumor suppressor KMT2C is recurrently deleted in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly therapy-related MDS/AML (t-MDS/t-AML), as part of larger chromosome 7 deletions. Here, we show that KMT2C deletions convey a selective advantage to hematopoietic...
Autores principales: | Chen, Ran, Okeyo-Owuor, Theresa, Patel, Riddhi M., Casey, Emily B., Cluster, Andrew S., Yang, Wei, Magee, Jeffrey A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951951/ https://www.ncbi.nlm.nih.gov/pubmed/33596429 http://dx.doi.org/10.1016/j.celrep.2021.108751 |
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