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Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling
Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis, an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951984/ https://www.ncbi.nlm.nih.gov/pubmed/33647060 http://dx.doi.org/10.1371/journal.ppat.1009365 |
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author | Wang, Yanping Wu, Xiaotong Wang, Zehua Chen, Ting Zhou, Sicong Chen, Jiani Pang, Lan Ye, Xiqian Shi, Min Huang, Jianhua Chen, Xuexin |
author_facet | Wang, Yanping Wu, Xiaotong Wang, Zehua Chen, Ting Zhou, Sicong Chen, Jiani Pang, Lan Ye, Xiqian Shi, Min Huang, Jianhua Chen, Xuexin |
author_sort | Wang, Yanping |
collection | PubMed |
description | Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis, an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess secretion of P. xylostella tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in the midgut of the parasitized host larvae. We found that parasitization upregulates PxTK signaling to suppress lipogenesis in midgut enterocytes (ECs) in a non-cell-autonomous manner, and the reduced host lipid level benefits the development of wasp offspring and their subsequent parasitic ability. We further found that a C. vestalis bracovirus (CvBV) gene, CvBV 9–2, is responsible for PxTK induction, which in turn reduces the systemic lipid level of the host. Taken together, these findings illustrate a novel mechanism for parasite manipulation of host energy homeostasis by a symbiotic bracovirus gene to promote the development and increase the parasitic efficiency of an agriculturally important wasp species. |
format | Online Article Text |
id | pubmed-7951984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-79519842021-03-22 Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling Wang, Yanping Wu, Xiaotong Wang, Zehua Chen, Ting Zhou, Sicong Chen, Jiani Pang, Lan Ye, Xiqian Shi, Min Huang, Jianhua Chen, Xuexin PLoS Pathog Research Article Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis, an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess secretion of P. xylostella tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in the midgut of the parasitized host larvae. We found that parasitization upregulates PxTK signaling to suppress lipogenesis in midgut enterocytes (ECs) in a non-cell-autonomous manner, and the reduced host lipid level benefits the development of wasp offspring and their subsequent parasitic ability. We further found that a C. vestalis bracovirus (CvBV) gene, CvBV 9–2, is responsible for PxTK induction, which in turn reduces the systemic lipid level of the host. Taken together, these findings illustrate a novel mechanism for parasite manipulation of host energy homeostasis by a symbiotic bracovirus gene to promote the development and increase the parasitic efficiency of an agriculturally important wasp species. Public Library of Science 2021-03-01 /pmc/articles/PMC7951984/ /pubmed/33647060 http://dx.doi.org/10.1371/journal.ppat.1009365 Text en © 2021 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Wang, Yanping Wu, Xiaotong Wang, Zehua Chen, Ting Zhou, Sicong Chen, Jiani Pang, Lan Ye, Xiqian Shi, Min Huang, Jianhua Chen, Xuexin Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling |
title | Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling |
title_full | Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling |
title_fullStr | Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling |
title_full_unstemmed | Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling |
title_short | Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling |
title_sort | symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951984/ https://www.ncbi.nlm.nih.gov/pubmed/33647060 http://dx.doi.org/10.1371/journal.ppat.1009365 |
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