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Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma
PURPOSE: To investigate the influence of microcystic, elongated and fragmented (MELF) pattern invasion on preoperative evaluation of lymph node (LN) metastasis and myometrial invasion in patients with low-grade endometrial carcinoma. METHODS: The study included 192 consecutive patients with low-grad...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society for Magnetic Resonance in Medicine
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952211/ https://www.ncbi.nlm.nih.gov/pubmed/32074591 http://dx.doi.org/10.2463/mrms.mp.2019-0153 |
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author | Kuwahara, Ryo Kido, Aki Yajima, Ryo Nishio, Naoko Nakao, Kyoko Kurata, Yasuhisa Tanaka, Shiro Minamiguchi, Sachiko Baba, Tsukasa Mandai, Masaki Togashi, Kaori |
author_facet | Kuwahara, Ryo Kido, Aki Yajima, Ryo Nishio, Naoko Nakao, Kyoko Kurata, Yasuhisa Tanaka, Shiro Minamiguchi, Sachiko Baba, Tsukasa Mandai, Masaki Togashi, Kaori |
author_sort | Kuwahara, Ryo |
collection | PubMed |
description | PURPOSE: To investigate the influence of microcystic, elongated and fragmented (MELF) pattern invasion on preoperative evaluation of lymph node (LN) metastasis and myometrial invasion in patients with low-grade endometrial carcinoma. METHODS: The study included 192 consecutive patients with low-grade endometrial carcinoma who underwent preoperative computed tomography (CT) and magnetic resonance imaging (MRI), followed by surgery. One hundred sixty one of 192 patients underwent LN dissection and were analyzed for LN metastasis. All patients were analyzed for myometrial invasion. Presence of enlarged LN was evaluated by using size criteria on CT. Depth of myometrial invasion was evaluated on MRI using T(2)-weighted imaging, diffusion-weighted imaging and contrast-enhanced T(1)-weighted imaging comprehensively. Sensitivity and specificity for LN metastasis and deep myometrial invasion were evaluated for MELF group and non-MELF group. The difference of sensitivity between two groups was compared using Chi-square and Fisher’s exact test. RESULTS: MELF pattern invasion was identified in 43/192 patients (22%). LN metastases were observed in 18/39 patients in MELF group and 6/122 patients in non-MELF group for pelvic LN and 11/29 patients in MELF group and 4/57 patients in non-MELF group for para-aortic LN. Sensitivity for the detection of pelvic LN metastasis in MELF group was significantly lower than in non-MELF group (16.7% vs 66.7%). As for the assessment of the deep myometiral invasion, pathological deep myometrial invasion were found in 31/43 patients in MELF group and 32/149 patients in non-MELF group. Sensitivity in MELF group showed lower values than in non-MELF group (54.8% vs 78.1% for reader 1, 54.8% vs 62.5% for reader 2), although there was no statistically significant difference (P = 0.09 for reader 1 and P = 0.72 for reader 2). CONCLUSION: In case of low-grade endometrial carcinoma with MELF pattern invasion, preoperative staging by CT and MRI have a risk for underestimation. |
format | Online Article Text |
id | pubmed-7952211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Japanese Society for Magnetic Resonance in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-79522112021-03-16 Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma Kuwahara, Ryo Kido, Aki Yajima, Ryo Nishio, Naoko Nakao, Kyoko Kurata, Yasuhisa Tanaka, Shiro Minamiguchi, Sachiko Baba, Tsukasa Mandai, Masaki Togashi, Kaori Magn Reson Med Sci Major Paper PURPOSE: To investigate the influence of microcystic, elongated and fragmented (MELF) pattern invasion on preoperative evaluation of lymph node (LN) metastasis and myometrial invasion in patients with low-grade endometrial carcinoma. METHODS: The study included 192 consecutive patients with low-grade endometrial carcinoma who underwent preoperative computed tomography (CT) and magnetic resonance imaging (MRI), followed by surgery. One hundred sixty one of 192 patients underwent LN dissection and were analyzed for LN metastasis. All patients were analyzed for myometrial invasion. Presence of enlarged LN was evaluated by using size criteria on CT. Depth of myometrial invasion was evaluated on MRI using T(2)-weighted imaging, diffusion-weighted imaging and contrast-enhanced T(1)-weighted imaging comprehensively. Sensitivity and specificity for LN metastasis and deep myometrial invasion were evaluated for MELF group and non-MELF group. The difference of sensitivity between two groups was compared using Chi-square and Fisher’s exact test. RESULTS: MELF pattern invasion was identified in 43/192 patients (22%). LN metastases were observed in 18/39 patients in MELF group and 6/122 patients in non-MELF group for pelvic LN and 11/29 patients in MELF group and 4/57 patients in non-MELF group for para-aortic LN. Sensitivity for the detection of pelvic LN metastasis in MELF group was significantly lower than in non-MELF group (16.7% vs 66.7%). As for the assessment of the deep myometiral invasion, pathological deep myometrial invasion were found in 31/43 patients in MELF group and 32/149 patients in non-MELF group. Sensitivity in MELF group showed lower values than in non-MELF group (54.8% vs 78.1% for reader 1, 54.8% vs 62.5% for reader 2), although there was no statistically significant difference (P = 0.09 for reader 1 and P = 0.72 for reader 2). CONCLUSION: In case of low-grade endometrial carcinoma with MELF pattern invasion, preoperative staging by CT and MRI have a risk for underestimation. Japanese Society for Magnetic Resonance in Medicine 2020-02-19 /pmc/articles/PMC7952211/ /pubmed/32074591 http://dx.doi.org/10.2463/mrms.mp.2019-0153 Text en © 2021 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Major Paper Kuwahara, Ryo Kido, Aki Yajima, Ryo Nishio, Naoko Nakao, Kyoko Kurata, Yasuhisa Tanaka, Shiro Minamiguchi, Sachiko Baba, Tsukasa Mandai, Masaki Togashi, Kaori Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma |
title | Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma |
title_full | Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma |
title_fullStr | Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma |
title_full_unstemmed | Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma |
title_short | Microcystic, Elongated and Fragmented Pattern Invasion Can Adversely Influence Preoperative Staging for Low-grade Endometrial Carcinoma |
title_sort | microcystic, elongated and fragmented pattern invasion can adversely influence preoperative staging for low-grade endometrial carcinoma |
topic | Major Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952211/ https://www.ncbi.nlm.nih.gov/pubmed/32074591 http://dx.doi.org/10.2463/mrms.mp.2019-0153 |
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