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Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk
High alcohol intake and breast density increase breast cancer (BC) risk, but their interrelationship is unknown. We examined whether volumetric density modifies and/or mediates the alcohol-BC association. BC cases (n = 2233) diagnosed from 2006 to 2013 in the San Francisco Bay area had screening mam...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952225/ https://www.ncbi.nlm.nih.gov/pubmed/33733051 http://dx.doi.org/10.1093/jncics/pkaa124 |
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author | Rustagi, Alison S Scott, Christopher G Winham, Stacey J Brandt, Kathleen R Norman, Aaron D Jensen, Matthew R Shepherd, John A Hruska, Carrie Heine, John J Pankratz, Vernon S Kerlikowske, Karla Vachon, Celine M |
author_facet | Rustagi, Alison S Scott, Christopher G Winham, Stacey J Brandt, Kathleen R Norman, Aaron D Jensen, Matthew R Shepherd, John A Hruska, Carrie Heine, John J Pankratz, Vernon S Kerlikowske, Karla Vachon, Celine M |
author_sort | Rustagi, Alison S |
collection | PubMed |
description | High alcohol intake and breast density increase breast cancer (BC) risk, but their interrelationship is unknown. We examined whether volumetric density modifies and/or mediates the alcohol-BC association. BC cases (n = 2233) diagnosed from 2006 to 2013 in the San Francisco Bay area had screening mammograms 6 or more months before diagnosis; controls (n = 4562) were matched on age, mammogram date, race or ethnicity, facility, and mammography machine. Logistic regression was used to estimate alcohol-BC associations adjusted for age, body mass index, and menopause; interaction terms assessed modification. Percent mediation was quantified as the ratio of log (odds ratios [ORs]) from models with and without density measures. Alcohol consumption was associated with increased BC risk (2-sided P(trend) = .004), as were volumetric percent density (OR = 1.45 per SD, 95% confidence interval [CI] = 1.36 to 1.56) and dense volume (OR = 1.30, 95% CI = 1.24 to 1.37). Breast density did not modify the alcohol-BC association (2-sided P > .10 for all). Dense volume mediated 25.0% (95% CI = 5.5% to 44.4%) of the alcohol-BC association (2-sided P = .01), suggesting alcohol may partially increase BC risk by increasing fibroglandular tissue. |
format | Online Article Text |
id | pubmed-7952225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-79522252021-03-16 Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk Rustagi, Alison S Scott, Christopher G Winham, Stacey J Brandt, Kathleen R Norman, Aaron D Jensen, Matthew R Shepherd, John A Hruska, Carrie Heine, John J Pankratz, Vernon S Kerlikowske, Karla Vachon, Celine M JNCI Cancer Spectr Brief Communications High alcohol intake and breast density increase breast cancer (BC) risk, but their interrelationship is unknown. We examined whether volumetric density modifies and/or mediates the alcohol-BC association. BC cases (n = 2233) diagnosed from 2006 to 2013 in the San Francisco Bay area had screening mammograms 6 or more months before diagnosis; controls (n = 4562) were matched on age, mammogram date, race or ethnicity, facility, and mammography machine. Logistic regression was used to estimate alcohol-BC associations adjusted for age, body mass index, and menopause; interaction terms assessed modification. Percent mediation was quantified as the ratio of log (odds ratios [ORs]) from models with and without density measures. Alcohol consumption was associated with increased BC risk (2-sided P(trend) = .004), as were volumetric percent density (OR = 1.45 per SD, 95% confidence interval [CI] = 1.36 to 1.56) and dense volume (OR = 1.30, 95% CI = 1.24 to 1.37). Breast density did not modify the alcohol-BC association (2-sided P > .10 for all). Dense volume mediated 25.0% (95% CI = 5.5% to 44.4%) of the alcohol-BC association (2-sided P = .01), suggesting alcohol may partially increase BC risk by increasing fibroglandular tissue. Oxford University Press 2021-02-04 /pmc/articles/PMC7952225/ /pubmed/33733051 http://dx.doi.org/10.1093/jncics/pkaa124 Text en © The Author(s) 2021. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Brief Communications Rustagi, Alison S Scott, Christopher G Winham, Stacey J Brandt, Kathleen R Norman, Aaron D Jensen, Matthew R Shepherd, John A Hruska, Carrie Heine, John J Pankratz, Vernon S Kerlikowske, Karla Vachon, Celine M Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk |
title | Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk |
title_full | Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk |
title_fullStr | Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk |
title_full_unstemmed | Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk |
title_short | Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk |
title_sort | association of daily alcohol intake, volumetric breast density, and breast cancer risk |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952225/ https://www.ncbi.nlm.nih.gov/pubmed/33733051 http://dx.doi.org/10.1093/jncics/pkaa124 |
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