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EMeth: An EM algorithm for cell type decomposition based on DNA methylation data

We introduce a new computational method named EMeth to estimate cell type proportions using DNA methylation data. EMeth is a reference-based method that requires cell type-specific DNA methylation data from relevant cell types. EMeth improves on the existing reference-based methods by detecting the...

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Detalles Bibliográficos
Autores principales:	Zhang, Hanyu, Cai, Ruoyi, Dai, James, Sun, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952399/ https://www.ncbi.nlm.nih.gov/pubmed/33707472 http://dx.doi.org/10.1038/s41598-021-84864-9

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