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Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age
BACKGROUND: Neonatal exposure to antibiotics, in the absence of infection, results in abnormal learning and memory in animals and is linked to changes in gut microbes. The relevance of early-life antibiotic exposure to brain function in humans is not known. METHODS: Recognition memory was assessed a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952463/ https://www.ncbi.nlm.nih.gov/pubmed/32919394 http://dx.doi.org/10.1038/s41390-020-01117-7 |
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author | Hickey, Marie K Miller, Neely C Haapala, Jacob Demerath, Ellen W Pfister, Kathleen M Georgieff, Michael K Gale, Cheryl A |
author_facet | Hickey, Marie K Miller, Neely C Haapala, Jacob Demerath, Ellen W Pfister, Kathleen M Georgieff, Michael K Gale, Cheryl A |
author_sort | Hickey, Marie K |
collection | PubMed |
description | BACKGROUND: Neonatal exposure to antibiotics, in the absence of infection, results in abnormal learning and memory in animals and is linked to changes in gut microbes. The relevance of early-life antibiotic exposure to brain function in humans is not known. METHODS: Recognition memory was assessed at 1 month of age in 15 term-born infants exposed to antibiotics (with negative cultures) and 57 unexposed infants using event-related potentials (ERPs). Linear regression analysis, adjusting for covariates, was employed to compare groups with respect to ERP features representing early stimulus processing (P2 amplitude) and discrimination between mother and stranger voices. RESULTS: Infants exposed to antibiotics exhibited smaller P2 amplitudes for both voice conditions (p = 0.001), with greatest reductions observed for mother’s voice in frontal and central scalp regions (p < 0.04). Infants exposed to antibiotics showed larger P2 amplitudes to stranger’s as compared to mother’s voice, a reversal of the typical response exhibited by unexposed infants. Abnormal ERP responses did not consistently correlate with increased inflammatory cytokines within the antibiotic-exposed group. CONCLUSION: Otherwise healthy infants exposed to antibiotics soon after birth demonstrated altered auditory processing and recognition memory responses, supporting the possibility of a microbiota-gut-brain axis in humans during early life. |
format | Online Article Text |
id | pubmed-7952463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-79524632021-05-31 Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age Hickey, Marie K Miller, Neely C Haapala, Jacob Demerath, Ellen W Pfister, Kathleen M Georgieff, Michael K Gale, Cheryl A Pediatr Res Article BACKGROUND: Neonatal exposure to antibiotics, in the absence of infection, results in abnormal learning and memory in animals and is linked to changes in gut microbes. The relevance of early-life antibiotic exposure to brain function in humans is not known. METHODS: Recognition memory was assessed at 1 month of age in 15 term-born infants exposed to antibiotics (with negative cultures) and 57 unexposed infants using event-related potentials (ERPs). Linear regression analysis, adjusting for covariates, was employed to compare groups with respect to ERP features representing early stimulus processing (P2 amplitude) and discrimination between mother and stranger voices. RESULTS: Infants exposed to antibiotics exhibited smaller P2 amplitudes for both voice conditions (p = 0.001), with greatest reductions observed for mother’s voice in frontal and central scalp regions (p < 0.04). Infants exposed to antibiotics showed larger P2 amplitudes to stranger’s as compared to mother’s voice, a reversal of the typical response exhibited by unexposed infants. Abnormal ERP responses did not consistently correlate with increased inflammatory cytokines within the antibiotic-exposed group. CONCLUSION: Otherwise healthy infants exposed to antibiotics soon after birth demonstrated altered auditory processing and recognition memory responses, supporting the possibility of a microbiota-gut-brain axis in humans during early life. 2020-09-12 2021-05 /pmc/articles/PMC7952463/ /pubmed/32919394 http://dx.doi.org/10.1038/s41390-020-01117-7 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Hickey, Marie K Miller, Neely C Haapala, Jacob Demerath, Ellen W Pfister, Kathleen M Georgieff, Michael K Gale, Cheryl A Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age |
title | Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age |
title_full | Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age |
title_fullStr | Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age |
title_full_unstemmed | Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age |
title_short | Infants exposed to antibiotics after birth have altered recognition memory responses at one month of age |
title_sort | infants exposed to antibiotics after birth have altered recognition memory responses at one month of age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952463/ https://www.ncbi.nlm.nih.gov/pubmed/32919394 http://dx.doi.org/10.1038/s41390-020-01117-7 |
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